Promestriene API

Promestriene is a synthetic form of estrogen, primarily used in local (topical) treatments for conditions related to estrogen deficiency. It’s often applied in gynecology to manage symptoms caused by reduced estrogen levels, especially in vaginal and vulvar tissues.

Medical Uses:

Vaginal Atrophy: It helps relieve symptoms like dryness, itching, and discomfort caused by thinning and inflammation of vaginal walls due to low estrogen levels (often seen in menopause).
Vulvovaginal Dystrophy: It supports the regeneration of vaginal and vulvar tissues.
Healing Support: It can promote healing after gynecological surgeries or injuries where estrogenic support helps tissue repair.
Sexual Health: Used to improve lubrication and comfort during intercourse in postmenopausal women.
Forms and Application:

Creams or Ointments: Applied locally to the affected area.
Suppositories: Inserted vaginally for internal relief.
How It Works: Promestriene mimics natural estrogen by binding to estrogen receptors in local tissues. This promotes cell regeneration, improves blood flow, and increases the thickness and elasticity of the vaginal walls — reducing symptoms like dryness and irritation.

Safety and Side Effects: Since it’s used topically and not systemically absorbed in large amounts, it generally has fewer side effects compared to systemic estrogen therapy. However, possible side effects can include:

Local irritation or itching
Increased vaginal discharge
Sensitivity or burning sensation
It’s usually well tolerated, but it’s always important to use it under medical supervision — especially for people with a history of hormone-sensitive conditions.